Bryon Anthony McCane was born in Columbus, Ohio. In 1980, 4-year-old Bryon and his two sisters were abducted and held captive for over two years by his stepfather. Both his sisters were natural children of Bryon's stepfather. The children were put into the backseat of a car and driven off, while their mother was at work. Bizzy Bone says that at first, he did not know he had been kidnapped, and was made to believe that his mother and grandmother were dead. During his abduction period, he lived in many homes, apartments, cars and motels, all in Northern Oklahoma. Bizzy Bone was often beaten, tortured, and sexually assaulted. In 1983, the "family" been living on the Kaw Indian Reservation in Kaw, Oklahoma for about a year-and-a-half. A neighbor saw his photo at the end of the made-for-TV movie, Adam, and called the police, resulting in his return to his family.
When he was thirteen, Bryon went to live with his sister oldest sister, at her home near Cleveland, Ohio. During this period he met Layzie Bone, Krayzie Bone, Wish Bone and Flesh-n-Bone. Bizzy Bone started in hip hop as a founding member of the group Bone Enterprise, which was formed in 1992. This Cleveland-based crew first got the ear of N.W.Afounder Eazy-E who bestowed the moniker Thugs-n-Harmony on the group. In 2002, he appeared on the FOX series America's Most Wanted (hosted by John Walsh, Adam's father)  and he revealed his abusive childhood and molestation. Bryon also wrote and performed a song on the show entitled "A.M.W." in which he thanks Walsh and encourages abused children to come forward. In 2003, he returned to Kaw City to see his former neighbors, and meet the man who helped save him. He says that although he has several bad memories here, he still considers Kaw City his hometown.
Bizzy Bone started his solo career in 1998. He is best known for his style of combining rapid fire raps, double harmony choruses, with a soft-spoken and high-pitched delivery. His solo debut, Heaven'z Movie, was critically acclaimed and certified Platinum by the RIAA.
The Gift, released on April 7, 2001, peaked at #2 on the US Billboard Independent Albumschart. Many of the songs on the album dealt with his personal life and childhood.
In 2004, Bizzy released Alpha and Omegawhich showed a change in his musical and lyrical content. Fans responded positively to the album. Bizzy followed up with the limited-edition internet album The Beginning and the End (album).